C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/735 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01) A61K 38/11 (2006.01)
Patent
CA 2141685
The invention relates to an antiallergic composition comprising, as an active ingredient, a peptide which is capable of binding to human IgE, more specifically a high affinity immunoglobulin E receptor .alpha.-chain or a soluble fragment, which is capable of binding to human IgE, of a high affinity immunoglobulin E receptor .alpha.-chain, (1) an animal cell transfected with a plasmid having inserted therein a DNA coding for sFc.epsilon.R.alpha. linked to a promoter capable of controlling the expression of the DNA in animal cells at upstream site thereof and a DNA coding for DHFR linked to a UK promoter at upstream site thereof, (2) an animal cell cotransfected with a plasmid carrying a DNA coding for sFc.epsilon.RI.alpha. linked to a promoter capable of controlling the expression of the DNA in animal cells at upstream site thereof and a plasmid carrying a DNA coding for DHFR linked to a UK promoter at upstream site thereof, and (3) a process for producing sFc.epsilon.RI.alpha. in a large quantity which comprises cultivating the animal cells of the above (1) or (2). The present invention provides a composition clinically useful for blocking allergic responses at their root.
Hirama Minoru
Naito Koji
Okumura Ko
Ra Chisei
Riches Mckenzie & Herbert Llp
Yoshitomi Pharmaceutical Industries Ltd.
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