Antiallergic composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/74 (2006.01) A23L 1/30 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 27/02 (2006.01) A61P 37/08 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2518947

It is intended to provide an antiallergic composition which is useful in preventing and treating allergy, a method of preparing the same and utilization thereof as foods, drinks, etc. An allergic composition containing, as the active ingredient, a lactic acid bacterium which shows an interleukin 12 productivity comparable to the case using L. paracasei KW3110 strain as a test lactic acid bacterium or at least 60% as much as the case using L. paracasei KW3110 strain and an interleukin 4 productivity less than 50% of the control case without adding any lactic acid bacteria, when cultured in an egg albumin-containing medium in which mouse spleen-origin lymphocytes having been sensitized with egg albumin are suspended. A method of obtaining the lactic acid bacterium having a high antiallergic activity, which is the active ingredient of the antiallergic composition; utilization of the antiallergic composition in foods, drinks, etc.; and utilization of the antiallergic composition by processing it into an antiallergic preparation for oral administration.

L'invention concerne une composition antiallergique utile pour la prévention et le traitement d'allergies, un procédé d'élaboration, et une utilisation de ce type de composition sous la forme d'aliment, de boisson, etc. Elle contient comme principe actif une bactérie d'acide lactique à productivité d'IL 12 comparable à celle du cas dans lequel on utilise une souche de L.paracasei KW3110 comme bactérie d'acide lactique d'essai ou équivalant au moins à 60 % de celle du cas dans lequel on utilise une souche de L.paracasei KW3110 et à productivité d'IL 4 inférieure à 50 % par rapport au cas témoin sans adjonction de bactérie d'acide lactique, après culture dans un milieu à albumine d'oeuf à l'intérieur duquel des lymphocytes de rate murine sensibilisés avec cette albumine sont en suspension. L'invention concerne un procédé de préparation de bactérie d'acide lactique à activité antiallergique élevée, qui est le principe actif de la composition considérée, ainsi que l'utilisation de cette composition sous la forme d'aliment, de boisson, etc., et son utilisation par traitement sous la forme de préparation antiallergique pour administration orale.

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