C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/14 (2006.01) A61K 31/55 (2006.01) C07D 487/14 (2006.01) C07D 491/147 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2150805
Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; R1 represents hydrogen, C1-4alkyl, halo, ethenyle substituted with hydroxycarbonyl or C1- 4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl, hydroxycarbonyl or hydroxycarbonylC1-4alkyl; R2 represents hydrogen, C1-4alkyl, ethenyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, C1-4alkyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1- 4alkyl, formyl or hydroxycarbonyl; R3 represents hydrogen, C1-4alkyl, hydroxyC1-4alkyl, phenyl or halo; X represents O, S or NR4; L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or a radical of the formula: -Alk-Y-Het1 (a- 1), -Alk-NH-CO-Het2 (a-2) or Alk-Het3 (a-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.
Diels Gaston Stanislas Marcella
Janssens Frans Eduard
Leenaerts Joseph Elisabeth
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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