Antiallergic imidazoazepines

Details Antiallergic imidazoazepines Antiallergic imidazoazepines

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/55 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01) C07D 491/14 (2006.01) C07D 491/147 (2006.01) C07D 495/14 (2006.01) C07D 498/14 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2165800

The present invention is concerned with novel imidazoazepines of formula (I), the: pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently r<;presents an optional bond; -A-B- is a radical of formula -X-CH=CH- (a-1); -CH=CH-X- (a-2); or -CH=CH-CH=CH- (a-3); X represents O, S or NR1; R1 represents hydrogen or C1-6alkyl; _~ Y is a radical of formula =O (b-1); -OH (b-2); or =N-OH (b-3); and L represents hydrogen, C1-4alkylcarbonyl, C1-4alkyloxycarbonyl, phenylcarbonyl, C1-6alkyl or C1-6alkyl substituted with C1-4alkyloxycarbonyl, hydroxycarbonyl, aryl, aryloxy or a radical of formula (c), wherein -D-Z. is -S-CH=CH-, -S-CH2-CH2-, -S-CH2-CH2-CH2-, -CH=CH-CH=CH- or - CH2-CH2-CH2-CH2-; and aryl is phenyl or phenyl substituted with halo, hydtnxy or C1-4alkyloxy. Compositions comprising said compounds, processes for preparing the same and the use of these compounds for treating allergic diseases.

L'invention concerne de nouvelles imidazoazépines ayant la formule (I), leurs sels d'addition et leurs formes stéréochimiquement isomères pharmaceutiquement acceptables. Dans la formule (I), chaque ligne en pointillé représente une liaison facultative; -A-B- est un radical ayant les formules -X-CH=CH- (a-1), -CH=CH-X- (a-2) ou -CH=CH-CH=CH- (a-3); X désigne O, S ou NR<1>, R<1> désigne hydrogène ou alkyle C1-6; - &cir& NOt - &cir& NOt - &cir& NOt - &cir& NOt Y désigne un radical ayant les formules =0 (b-1), -OH (b-2) ou =N-OH (b-3); et L désigne hydrogène, alkylcarbonyle C1-4, alkyloxycarbonyle C1-4, phénylcarbonyle, alkyle C1-6 ou alkyle C1-6 substitué par alkyloxycarbonyle C1-4, hydroxycarbonyle, aryle, aryloxy ou un radical ayant la formule (c), dans laquelle -D-Z- désigne -S-CH=CH-, -S-CH2-CH2, -S-CH2-CH2-CH2, -CH=CH-CH=CH- ou -CH2-CH2-CH2-CH2-; et aryle désigne phényle ou phényle substitué par halo, hydroxy ou alkyloxy C1-4. L'invention concerne également des compositions contenant ces composés, des procédés de préparation de ces composés et leur utilisation dans le traitement de maladies allergiques.

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