Antiallergic triazolobenzazepine derivatives

Details Antiallergic triazolobenzazepine derivatives Antiallergic triazolobenzazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2150806

Antiallergic triazolobenzazepines of formula (I), wherein each of the dotted lines independently represents an optional bond; R1 represents hydrogen, halo, c1-4alkyl, hydroxy or C1-4alkyloxy R2 represents hydrogen, halo, C1-4alkyl, hydroxy or C1-4alkyloxy; R3 represents hydrogen C1-4alkyl or halo; -B D- is a bivalent radical of formula -C(R4) N-(a-1); or -N C(R5)- (a-2); R4 and R5 represent hydrogen, C1-4alkyl, ethenyl substituted with hydroxycarbonyl or C1- 4alkyloxycarbonyl, C1-4alkyl substituted with hydroxycarbonyl or C1- 4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl or hydroxycarbonyl; R5 also represents phenyl or pyridinyl; L represents hydrogen; C1-6alkyl; substituted C1-6alkyl, C3-6alkenyl; C3-6alkenyl substituted with aryl or, L represents a radical of formula -Alk-Y-Het1 (b-1), -Alk-NH- CO-Het2 (b-2) or -Alk-Het3 (b-3). Compositions comprising said compounds, processes of preparing the same, and intermediates in the preparation thereof.

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