Antiandrogenic sulfonylsteroidopyrazoles and processes for...

Details Antiandrogenic sulfonylsteroidopyrazoles and processes for... Antiandrogenic sulfonylsteroidopyrazoles and processes for...

C - Chemistry, Metallurgy

07

J

260/11, 167/191

C07J 71/00 (2006.01) A61K 31/58 (2006.01) C07J 1/00 (2006.01) C07J 17/00 (2006.01) C07J 31/00 (2006.01)

Patent

CA 1255294

ABSTRACT OF THE DISCLOSURE 1'-Sulfonylsteroido[3,2-c]pyrazoles of formula (I) below, for example, (5.alpha. ,17.alpha.)-1'-(methylsulfonyl)-1'H-pregn- 20-yno[3,2-c]pyrazol-17-ol, which are useful as antiandrogenic agents, and processes for preparation, method of use and compo- sitions thereof are disclosed: Image (I) wherein X is -CH3, -CH2CH3, -CH2CH2CH3 or -CH2C1; Y-Z is Image , CH=C, Image ; R6 is H or -CH3 when Y-Z is CH=C or is H when Y-Z is other than CH=C; R10 is H or CH3; R17.alpha. taken alone is -H, -CH3, -CH2CH3, -CH=CH2, -C?CH or -C?CBr; R17.beta. taken alone is -OH, -OCOCHC12, -OCOCF3, -OCH3, -OCH2SCH3, -OCH2SOCH3, -OCH2SO2CH3 or Image ; and R17.alpha. and R17.beta. taken together represents -OCH2CH2O.

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