Antiangiogenic compounds and an assay for inhibitors of cell...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/12 (2006.01) A61K 31/395 (2006.01) A61K 31/403 (2006.01) A61P 35/00 (2006.01) C07D 209/86 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2435633

This invention provides the use of macrocyclic amines for inhibition of cellular invasion or angiogenesis. Compounds and pharmaceutical compositions of this invention are useful in the treatment of conditions characterized by cellular invasion or angiogenesis, including cancer. Compounds that may be used in this invention include the motuporamines.

L'invention concerne l'utilisation des amines macrocycliques dans l'inhibition de l'invention cellulaire ou l'angiogenèse. Les composés et compositions pharmaceutiques de cette invention sont utiles dans le traitement des états caractérisés par l'invasion cellulaire ou l'angiogenèse, y compris le cancer. Les composés pouvant s'utiliser dans cette invention comprennent les motuporamines.

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