Antiarrhythmic agents

Details Antiarrhythmic agents Antiarrhythmic agents

C - Chemistry, Metallurgy

07

C

167/179, 260/541

C07C 217/86 (2006.01) C07C 311/08 (2006.01) C07C 323/67 (2006.01) C07D 295/192 (2006.01)

Patent

CA 1289140

Abstract Title: Antiarrhythmic Agents Compounds of the formula:- Image --- (A) and their salts, wherein Ra is NO2, -NH2 or -NHSO2R1 where R1 is a C1-C4 alkyl group; Rb is -NO2, -NH2 or R3 where R3 is -NHSO2(C1-C4 alkyl) or -CONR4R5 where R4 and R5 are each independently H or C1-C4 alkyl or together with the nitrogen atom to which they are attached represent a 1-pyrrolidinyl, piperidino, morpholino or N-methylpiperazin-1-yl group; with the proviso that when one of Ra and Rb is -NO2, then the other is not -NH2; X is O, S or a direct link; Y is an ethylene group optionally substituted by a methyl group; "alk" is an ethylene, trimethylene or tetramethylene group, "alk" being optionally substituted by a methyl group; R is C1-C4 alkyl; and R is H, halo, CF3 or C1-C4 alkyl. The compounds of the formula (A) in which R is -NHSO2R1 and Rb is R3, R1 and R3 being as defined above, are cardiac antiarrhythmlc agents. The remaining compounds of the formula (A) are synthetic intermediates.

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