C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 243/24 (2006.01) A61K 31/55 (2006.01) A61K 45/06 (2006.01) C07D 243/12 (2006.01) C07D 243/14 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2257948
A method of preventing, treating, terminating and protecting against cardiac arrhythmias, such as atrial, supraventricular and ventricular ectopy, tachycardia, flutter or fibrillation, including atrial, supraventricular and ventricular arrhythmias resulting from myocardial ischemic injury in a patient in need thereof, comprising administration of a selective IKs antagonist and a beta-adrenergic receptor blocking agent, administered in combined therapy either simultaneously, separately or sequentially is presented. Additionally, a pharmaceutical preparation comprising a selective IKs antagonist and a beta- adrenergic receptor blocking agent, wherein these compounds are administered simultaneously, separately or sequentially is presented.
La présente invention a trait à une méthode de prévention, de traitement, de guérison et de protection concernant les arythmies cardiaques, telles que les ectopies de type auriculaire, supraventriculaire et ventriculaire, la tachycardie, le flutter ou la fibrillation, y compris les arythmies cardiaques auriculaires, supraventriculaires et ventriculaires résultant d'un traumatisme d'ischémie myocardiaque chez un patient nécessitant ledit traitement. La méthode comprend l'administration d'un antagoniste d'I¿Ks? sélectif et d'un bêta-bloquant, administrés selon une polythérapie simultanée, séparée ou séquentielle. En outre, l'invention concerne une préparation pharmaceutique comprenant un antagoniste d'I¿Ks? sélectif et un bêta-bloquant, ces composés étant administrés simultanément, séparément ou séquentiellement.
Lynch Joseph J. Jr.
Salata Joseph J.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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