Antiarrhythmic precursor compounds, methods of synthesis and...

Details Antiarrhythmic precursor compounds, methods of synthesis and... Antiarrhythmic precursor compounds, methods of synthesis and...

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/35 (2006.01)

Patent

CA 2612599

The invention comprises compounds of Formula 1: wherein, R1 is independently H or halogen; R2 is, for example, H or -R10-NR11R12, and wherein R10 is C1-C6 alkyl, and R11 and R12 are independently H, C1-C4 alkyl, and hydrates, solvates, salts and tautomers thereof. The invention further comprises methods for making the compounds of the invention and methods for making compounds useful in the treatment or prevention of cardiac arrhythmia from the compounds of the invention.

La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle : R1 représente indépendamment H ou halogène ; R2 représente, par exemple, H ou -R10-NR11R12, où R10 représente alkyle C1-C6, et R11 et R12 représentent indépendamment H, alkyle C1-C4. L'invention a également trait à des hydrates, à des solvates, à des sels et à des tautomères desdits composés. L'invention concerne aussi des procédés de préparation des composés selon l'invention, ainsi que des procédés de préparation de composés utiles pour traiter ou prévenir l'arythmie cardiaque à partir des composés selon l'invention.

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