C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/272
C07D 471/08 (2006.01) C07D 453/02 (2006.01)
Patent
CA 1107734
ANTIARRHYTHMIC QUINUCLIDINE CARBOXYLIC ACID XYLIDIDE AND METHOD OF PRODUCING THE SAME AND SIMILAR COMPOUNDS ABSTRACT OF THE DISCLOSURE The invention relates to the compound 2-6-xylidide of quinuclidine-3-carboxylic acid and its pharmaceutically acceptable salts, such as the hydrochloride, which have been found to be effective antiarrhythmic agents. The invention further relates to the production of this antiarrhythmic compound which method is applicable also to the production of related compounds which, however, do not have antiarrhythmic action, e.g. the quinuclidine-2-carboxylic acid xylidides. The compounds are produced according to this method by reacting the quinuclidine carboxylic acid in anhydrous chloroform and oxalyl chloride with the dimethylaniline. The desired compound is produced in high yield with a high degree of purity.
295163
Cohen Sasson
Kaplinsky Eliezer
Oppenheimer Edna
Purdue Frederick Company (canada) Ltd. (the)
Smart & Biggar
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