Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides

Details Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides

C - Chemistry, Metallurgy

07

C

C07C 311/08 (2006.01) A61K 31/18 (2006.01) A61K 31/22 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 295/135 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2060326

Compounds of formula (I) and pharmacologically acceptable salts thereof wherein: n is 1 to 3, R is an alkyl, R1 is hydrog- en or alkyl, R2 is alkyl, R3 is an alkyl; b) alkyl substituted with an aryl, heteroaryl or cycloalkyl; e) alkyl substituted with one to eight fluorine atoms; d) cycloalkyl; e) alkenyl; f) alkyl substituted with one to three hydroxy, acyloxy or alkoxy substitu- ents, and where the sum of carbons in R2 and R3 is greater than five or where R2 and R3 with the nitrogen atom form a satu- rated heterocyclic group having one nitrogen and form 4-8 carbon atoms or a 4- substituted piperazine group in which the 4-substituent can be alkyl, aryl, benzyl, or heteroaryl, and X is hydrogen, hydroxy, alkoxy, alkyl, carbon trifluoride or a ha- logen, or compounds of formula (I') and pharmacologically acceptable salts thereof wherein: n is 1 to 3, R is an alkyl, R1 is hydrogen or alkyl, R2 is an alkyl, R3 is an alkyl substituted with an aryl, heteroaryl or cycloalkyl, or an alkyl substituted with one to eight fluorine atoms, one to three hydroxy, acyloxy or alkoxy substituents, and where the sum of carbons in R2 and R3 is greater than five; X is hydrogen, hydroxy, alkoxy, alkyl, carbon trifluoride or a halogen, useful as class III antiarrhyth- mic agents.

Affiliated with

Also associated with

Rating

Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiarrhythmic tertiary amine-alkenyl-phenyl-alkanesulfonamides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1680680