Antibacterial agents

Details Antibacterial agents Antibacterial agents

C - Chemistry, Metallurgy

07

D

260/244.7

C07D 498/04 (2006.01) C07C 59/66 (2006.01) C07D 205/085 (2006.01) C07D 309/12 (2006.01) C07D 317/28 (2006.01) C07D 498/14 (2006.01)

Patent

CA 1092110

O-2-Isocephem Antibacterial Agents Abstract of the Invention There is described the stereoselective total synthesis of novel .DELTA.2,3-1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1, 6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula Image wherein Z is halo, hydroxyl, etherified hydroxyl or hydroxyl esterified with a carboxylic acid residue or a sulfonic acid residue and X is amino, azido or acyl- amino. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents. - 1 -

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