Antibacterial agents from streptomycete

C - Chemistry – Metallurgy – 12 – P

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C12P 17/10 (2006.01) C07D 487/04 (2006.01)

Patent

CA 1125204

ABSTRACT OF THE INVENTION It has been found that novel antibiotics can be obtained by the fermentation of strains of Streptomyces olivaceus. These antibiotics have a wide spectrum of activity and when pure are extremely potent inhibitors of the growth of many gram-positive and gram-negative bacteria. They can also enhance the effectiveness of penicillins and cephalosporins against certain .beta.-lactamase producing bacteria. These novel antibiotics are of the formula (I) and (II): Image (I) Image (II) Each of compounds (I) and (II) can be presented in cis - or trans-forms or as mixtures thereof.

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