C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/104.1
C07D 499/70 (2006.01) C07D 207/16 (2006.01) C07D 207/28 (2006.01) C07D 213/80 (2006.01) C07D 213/85 (2006.01) C07D 499/00 (2006.01) C07F 7/10 (2006.01)
Patent
CA 1144158
~OVEL h,lYTI3ACTERIA~ A~ -DE CCMPO~lN3S PAND PV~OC E S S ~M~_S OR ~R~ ~ ~ C ~ ~G 1`_ S 1~ ME ~bstract_of _e Disclosu e ~ ovel o~ganic ami~e ccm~ourids w;~ich ara .~ o- [(acyla,.,inoQcyl2mino or aminoa_yla~ino~ph~n~yl~-1,2- di~i~ro-~-oxoi-icotlnyl; pPnicillir. com~o~lnds having ~roc2 s?ectrum ~ntibacteri~l ~tili.y are p-oviQec ;~y ~a) reacting the C~ee a~ino acid of the appropriate penicillin or the acid sal~ or silylated derivative or complex thereof ~ith a reactivQ de~ivaLive of the c~r- responding i~l-6-~(acvl~minoacylamino or aminoacyla~.irlo)- phenyl]-l,~-dihydro-2-oxonicotin~c acid or (b) reac~ing tne free a.~ino acid 6-a~inspenicill~nic acic or a relateQ co~pound or the acid sal~ or silylated deri~a- tive Lhereof wi,h a reac;~ive derivative OL ~he corre- spondir.g D~ 6-~( acylamlnoacyla~ino or a~,inoacyl am~ino! -phenyl3-1,2-dihydro-~-oxonicotinyl!-2--substi uted glycine. ~harmaceutical Co~?Gsitions containin~ said compounds and methods for treating infections using said composi~icns are also disclosed.
347421
Haskell Theodore H.
Huang Gin G.
Hutt Marland P.
Nicolaides Ernest D.
Woo Peter W.k.
Macrae & Co.
Warner-Lambert Company
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