Antibacterial amide compounds and process means for...

Details Antibacterial amide compounds and process means for... Antibacterial amide compounds and process means for...

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/24 (2006.01) C07D 213/80 (2006.01) C07D 213/85 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1147324

NOVEL ANTIBACTERIAL AMIDE COMPOUNDS AND PROCESS MEANS FOR PRODUCING THE SAME Abstract of the Disclosure Novel organic amide compounds which are N-[6- [(acylaminoacylamino or aminoacylamino)phenyl]-1,2- dihydro-2-oxonicotinyl]cephalosporin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate cephalosporin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacyl- amino)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 7-aminocephalosporanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl]- 2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.

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