Antibacterial amide-macrocycles v

Details Antibacterial amide-macrocycles v Antibacterial amide-macrocycles v

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 38/03 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/02 (2006.01) C07K 5/08 (2006.01) C07K 7/02 (2006.01)

Patent

CA 2602755

The invention relates to antibacterial amide-macrocycles of formula (I), in which R26 represents hydrogen, halogen, amino or methyl, R7 represents a group of formula (II), (III), (IV) or (V), where R1 represents hydrogen or hydroxy and * stands for the bonding point on the carbon atom, and R2 represents hydrogen or methyl. The invention also relates to a method for producing said macrocycles, to their use for the treatment and/or prophylaxis of diseases and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infections.

L'invention concerne des amides macrocycliques antibactériens de formule (I) dans laquelle R26 représente hydrogène, halogène, amino ou méthyle, R7 représente un groupe de formules (II), (III), (IV) ou (V), dans lesquelles R1 représente hydrogène ou hydroxy, *représente le site de liaison à l'atome de carbone, R2 représente hydrogène ou méthyle. L'invention concerne également des procédés de production de ces amides macrocycliques, leur utilisation pour le traitement et/ou la prophylaxie de maladies ainsi que leur utilisation pour la production de médicaments servant au traitement et/ou à la prophylaxie de maladies, notamment d'infections bactériennes.

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