C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/262.5
C07D 239/49 (2006.01) A61K 31/635 (2006.01) C07D 239/48 (2006.01) C07D 295/145 (2006.01)
Patent
CA 1187497
Abstract Compounds of the formula (IV): Image or acid addition salts thereof, wherein one of the groups R5 is a group O(CH2)nYR7 wherein Y is an oxygen or sulphur atom or a methylene, OCH2 or SCH2 group, n is an integer from I to 5 and R7 is an optionally substituted phenyl group; the other group R5 and R6 being the same or different, each being hydrogen, halogen, C2-4alkenyl,C2-4alkenyloxy, nitro,cyano,hydroxy,benzyloxy, C1-4alkyl or C1-4alkoxy, the alkyl or alkoxy group being substituted by halogen, hydroxy, or C1-2alkoxy amino optionally substituted by one or two C1-4alky1 or C1-4acyl groups or the nitrogen atom forming part of a five or six membered heterocyclic ring, a group -OSO2R8 or S(O)rR8 wherein R8 is C1-3alkyl and r is 0,1 or 2 a group -COR9 wherein R9 is methyl,ethyl,methoxy,ethoxy,amino,methylamino,ethyl- amino, dimethylamino or diethylamino, are useful for the treatment of bactcrial infections. A process for preparing these compounds and novel chemical intermediates used in their preparation are disclosed as is the first medical use of the compounds of the formula (IV) are pharmaceutical compositions containing them.
391013
Rauckman Barbara S.
Roth Barbara
Marcoux & Sher Swabey Mitchell Houle
Wellcome Foundation Limited (the)
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