A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) C07D 477/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2306965
Carbapenems substituted with a naphthosultam at position 2 and linked through a CH2 group are disclosed. Pharmaceutical compositions and methods of treatment are also included. The naphtosultam is substituted with at least one cationic group -A-Q-L-B : (I). A-Q-L-B represents a side chain wherein in part: Q is formula (II) and (B) represents formulae (III) or (IV). The carbapenenems of the present invention are useful against gram positive microorganisms, especially methicillin resistant Staphylococci.
L'invention concerne des carbapénèmes à substitution naphtosultame en position 2 et liés par un groupe CH¿2?. L'invention concerne également des compositions pharmaceutiques et des méthodes de traitement. Le naphtosultame est substitué par au moins un groupe cationique -A-Q-L-B: (I). A-Q-L-B représente une chaîne latérale dans laquelle en partie: Q représente (II) et B représente (III) ou (IV). Les carbapénèmes de la présente invention sont utiles contre des micro-organismes Gram positif notamment des staphylocoques résistant à la méthicilline.
Cama Lovji D.
Ratcliffe Ronald W.
Sun Wanying
Wildonger Kenneth J.
Wilkening Robert R.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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