Antibacterial composition for oral administration

Details Antibacterial composition for oral administration Antibacterial composition for oral administration

A - Human Necessities

61

K

A61K 31/545 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/546 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2234426

-55- A new, antibacterial composition for use in oral administration is now provided, which composition comprises a mixture of Cefditoren pivoxyl with a water soluble casein salt. This composition has a reduced bitter taste of Cefditoren pivoxyl and also has improved properties regarding the rate and concentration of dissolution of Cefditoren pivoxyl in water and a ratio of dissolution out of Cefditoren pivoxyl into water. This composition further can attain a high absorbability of the Cefditoren component at the digestive tubes upon oral administration thereof. In this composition, the ratio (by weight) of Cefditoren pivoxyl to the casein salt added may preferably be in a range of 1:0.1 to 1:4. By further addition of a water-soluble polyphosphoric acid salt to the composition, the composition can prevent a ratio of dissolution out into water of the Cefditoren pivoxyl component being decreased when the composition was stored under severe conditions.

Cette invention concerne une nouvelle composition antibactérienne administrée par voie orale, laquelle comprend un mélange de pivoxil de cefditorène et de sel de caséine soluble dans l'eau. L'amertume du pivoxil de cefditorène contenu dans cette composition a été atténuée, tandis que ses propriétés concernant la vitesse de dissolution dans l'eau, la concentration et le taux d'élution ont été améliorées. Cette composition permet également d'obtenir une excellente absorption orale du principe à base de cefditorène. Dans cette composition, le rapport en poids du pivoxil de cefditorène par rapport au sel de caséine varie, de préférence, entre 1:0,1 et 1:4. Il est également possible, en ajoutant à cette composition un polyphosphate soluble dans l'eau, d'empêcher le taux d'élution de pivoxil de cefditorène de diminuer lors d'un stockage dans des conditions rigoureuses.

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