Antibacterial compositions containing 3-fluoro-d-alanine...

Details Antibacterial compositions containing 3-fluoro-d-alanine... Antibacterial compositions containing 3-fluoro-d-alanine...

A - Human Necessities

61

K

167/235

A61K 31/195 (2006.01) A61K 31/42 (2006.01) C07D 261/04 (2006.01)

Patent

CA 1039191

PATENT APPLICATION PAPERS OF FREDERICK M. KAHAN for ANTIBACTERIAL COMPOSITIONS CONTAINING 3-FLUORO- D-ALANINE TYPE COMPOUND AND N-SUBSTITUTED CYCLO- SERINE COMPOUND ABSTRACT OF THE DISCLOSURE Novel antibacterial compositions are prepared by combining 3-fluoro-D-alanine-type compound, such as 3-fluoro-D-alanine and its deutero analogs, and salts and esters thereof, with a 3-fluoro-D-alanine autoantagonist- inhibitor such as an N-substituted cycloserine-type compound. The compositions demonstrate highly effective antibacterial action at high levels of dosage of the 3-fluoro-D-alanine component and, in addition, possess a remarkable synergistic antibacterial action. - 1 -

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