A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/538 (2006.01) A61K 31/4439 (2006.01) A61K 31/5415 (2006.01) A61K 31/60 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2321265
Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.
Compositions antimicrobiennes contenant (1) un dérivé de rifamycine représenté par la formule (I) ou un sel physiologiquement acceptable de ce dérivé et, 2) (a) un inhibiteur de la pompe à protons ou (b) une préparation de bismuth, les composants (1) et (2) étant utilisés en des quantités permettant d'obtenir un effet synergique. Ces compositions peuvent être administrées aux patients souffrant de maladies digestives provoquées par l'infection par l'Helicobacter pylori, à petites doses et à faible fréquence d'administration, comparativement aux remèdes conventionnels.
Fujii Kenji
Hidaka Takayoshi
Hosoe Kazunori
Yamashita Katsuji
Activbiotics Pharma Llc
Kaneka Corporation
Osler Hoskin & Harcourt Llp
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