Antibacterial compounds

Details Antibacterial compounds Antibacterial compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2375630

Compounds of formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections, wherein: R1 is Ar or Het; R2 is H, C1-6alkyl or Ar-C0-6alkyl; X is H, C1-4alkyl, OR', SR', C1-4alkylsulfonyl, C1-4alkylsulfoxyl, CN, N(R')2, CH2N(R')2, NO2, CF3, CO2R', CON(R')2, COR', NR'C(O)R', F, Cl, Br, I, or CF3S(O)r-; R' is H, C1-6alkyl or Ar-C0-6alkyl; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.

L'invention concerne des composés de formule (I) qui sont des inhibiteurs Fab I, et qui sont utiles au traitement d'infections bactériennes, où R?1¿ représente Ar ou Het, R?2¿ désigne H, C¿1-6?alkyl ou Ar-C¿0-6?alkyl, X représente H, C¿1-4?alkyl, OR', SR', C¿1-4?alkylsulfonyl, C¿1-4?alkylsulfoxyl, CN, N(R')¿2?, CH¿2?N(R')¿2?, NO¿2?, CF¿3?, CO¿2?R', CON(R')¿2?, COR', NR'C(O)R', F, Cl, Br, I, ou CF¿3?S(O)¿r-?; R' désigne H, C¿1-6?alkyl ou Ar-C¿0-6?alkyl; et r est un nombre entier 0, 1 ou 2; ou un sel correspondant valide sur le plan pharmaceutique.

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