C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/18 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 235/20 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2204639
The invention concerns novel and known dibenzimidazoles of formula (I), in which R1 and R2 may be the same or different and are C6H4R3-, C6H3(OH)R4 or heterocyclyl, R3 represents hydroxy, amino, lower alkoxy or cyano, and R4 is halogen, lower alkyl or lower alkoxy, and pharmaceutically useful salts of compounds of general formula (I) which have an antibacterial effect, in particular against Staphylococcus, Enterococcus and Heliobacter pylori.
L'invention concerne des dibenzimidazoles connus et nouveaux de la formule (I) dans laquelle R?1¿ et R?2¿ peuvent être identiques ou différents et désignent C¿6?H¿4?R?3¿-, C¿6?H¿3?(OH)R?4¿- ou hétérocyclyle, R?3¿ désigne hydroxy, amino, alcoxy inférieur ou cyano et R?4¿ désigne halogène, alkyle inférieur ou alcoxy inférieur. L'invention concerne des sels de composés de la formule (I), utilisables sur le plan pharmaceutique et qui ont une action antibactérienne, notamment à l'égard du Staphylococcus, de l'Enterococcus et de l'Heliobacter pylori.
Haesler Walter
Ji Yu-Hua
Leupin Werner
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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