Antibacterial epimeric azahomoerythromycin a derivative and...

Details Antibacterial epimeric azahomoerythromycin a derivative and... Antibacterial epimeric azahomoerythromycin a derivative and...

C - Chemistry, Metallurgy

07

H

167/185, 260/230

C07H 17/00 (2006.01) A61K 31/71 (1985.01)

Patent

CA 1250284

ABSTRACT OF THE DISCLOSURE Disclosed are antibacterial 4"-epi-9-deoxo-9a-methyl-9a-aza- -9a-homoerythromycin A and pharmaceutically acceptable salts thereof. The antibacterial compound may be prepared by (a) methyl- ation of 4"-epi-deoxo-9a-aza-9a-homoerythromycin A, (b) N-deoxy- genation of 4"-epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A 3'-N-oxide or (c) hydrogenation of 4"-deoxy-4"-oxo-9-deoxo-9a- methyl-9a-aza-9a-homoerythromycin A. The antibacterial compound and its pharmaceutically acceptable salts can be formulated in pharmaceutical compositions and may be used in the treatment of bacterial infections in mammals.

562041

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