Antibacterial macrolactin a that bacillus polyfermenticus...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 1/20 (2006.01) A61K 31/365 (2006.01) A61P 31/04 (2006.01) C12P 17/02 (2006.01)

Patent

CA 2681041

The present invention relates to uses of Macrolactin A produced by Bacillus polyfermenticus KJS-2 (KCCM 10769P), which is a new bacillus strain, as an antibiotic. Macrolactin A of the present invention, which is produced by Bacillus polyfermenticus KJS-2, shows a broad spectrum of antibiotic activity against a variety of microorganisms and fungi, and is proved to be very efficient for the inhibition of particularly vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus Aureus (MRSA) that are multidrug-resistant bacteria. The antibiotic Macrolactin A produced by Bacillus polyfermenticus KJS-2, can be used as an excellent antibiotic against vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus Aureus (MRSA), and thus the present invention is a very useful invention for medical industry.

La présente invention concerne l'utilisation comme antibiotique de la macrolactine A produite par la nouvelle souche Bacillus polyfermenticus KJS-2 (KCCM 10769P). La macrolactine A de la présente invention produite par Bacillus polyfermenticus KJS-2 fait preuve d'un large spectre d'activité antibiotique contre divers microorganismes et champignons, s'avérant très efficace contre notamment les deux bactéries multirésistantes que sont l'entérocoque résistant à la vancomycine (VRE) et le staphylocoque doré résistant à la méthicilline (MRSA). La macrolactine A à action antibiotique produire par Bacillus polyfermenticus KJS-2 constitue un excellant antibiotique en utilisation contre l'entérocoque résistant à la vancomycine (VRE) et le staphylocoque doré résistant à la méthicilline (MRSA), ce qui en fait une invention très utile pour l'industrie médicale.

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