Antibacterial mycosaminosyl tylonolide and related macrolide...

Details Antibacterial mycosaminosyl tylonolide and related macrolide... Antibacterial mycosaminosyl tylonolide and related macrolide...

C - Chemistry, Metallurgy

07

H

260/230.35

C07H 17/08 (2006.01)

Patent

CA 1259307

ABSTRACT OF THE DISCLOSURE Antibacterial and intermediate substances which are derived by selective chemical transformation of partially hydrolyzed tylosin and related macrolide derivatives in which only the mycaminose sugar remains attached to the macrocyclic lactone ring. Compounds having particular utility as antibacterial agents have C-6 side chain aldehyde converted to a hydrazone, the C-3 ring hydroxy group acylated, and/or the C-14 hydroxymethyl group converted to a sulfonate or carboxylate ester, or to a halomethyl, aminomethyl, sulfonamidomethyl or carboxamidomethyl group. Compounds whose prime utility is as intermediates have side chain aldehyde group protected as an acetal, mycaminose sugar hydroxyls protected as carboxylate ester and/or C-14 hydroxymethyl converted to a formyl or azidomethyl group.

555983

Affiliated with

Also associated with

Rating

Antibacterial mycosaminosyl tylonolide and related macrolide... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibacterial mycosaminosyl tylonolide and related macrolide..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibacterial mycosaminosyl tylonolide and related macrolide... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1225314