Antibacterial penem compounds

Details Antibacterial penem compounds Antibacterial penem compounds

C - Chemistry, Metallurgy

07

D

C07D 499/88 (2006.01) A61K 31/43 (2006.01)

Patent

CA 2089369

Antibiotic penem coumpounds are represented by formula (I), wherein R represents a physiologically-hydrolyzable, ester- forming group. The physiologically hydrolyzable, ester-forming group useful in the penem compound of the present invention means a group which can be removed easily by in vivo hydrolysis, such as an acetyloxymethyl, 1-(acetyloxy)ethyl, pivaloyloxyme- thyl; 1-(ethoxycarbonyloxy)ethyl, 1-(isopropyloxycarbonyloxy)-ethyl, 1- (cyclohexyloxycarbonyloxy)ethyl or 3-phthalidyl group. Antibiotic compositions for oral administration are also described.

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