Antibacterial peptide

Details Antibacterial peptide Antibacterial peptide

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2499783

The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient. The present invention also provides for a peptide comprised of a sequence of cationic and non-polar or polar uncharged amino acids forming an .alpha.-helix wherein the amino acids are arranged along the .alpha.-helix such that when represented as a helical wheel, there is a substantial bi-lateral symmetry between cationic versus non-polar or polar uncharged amino acids.

Affiliated with

Also associated with

Rating

Antibacterial peptide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibacterial peptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibacterial peptide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2006398