Antibacterial peptides and analogues thereof

Details Antibacterial peptides and analogues thereof Antibacterial peptides and analogues thereof

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A01N 37/30 (2006.01) A61K 38/08 (2006.01) A61P 13/04 (2006.01)

Patent

CA 2570396

Antibacterial peptides and their multimeric analogues, with a wide range of action and low haemolytic activity are described. In particular, the peptide molecules exhibit a high antimicrobial activity against numerous bacterial species, with reduced cytotoxicity and a low haemolysis rate. The molecules of the invention are advantageously usable as therapeutic agents and coadjutants against infections caused by strains that are resistant to common antibiotics.

L'invention concerne des peptides antibactériens et leurs analogues multimères, présentant un rayon d'action étendu et une faible activité hémolytique. Les molécules de ces peptides possèdent une activité antibactérienne élevée contre de nombreuses espèces de bactéries, ainsi qu'une faible cytotoxicité et une vitesse d'hémolyse faible. Les molécules de l'invention peuvent être utilisées avantageusement en tant qu'agents thérapeutiques et coadjuvants contre les infections induites par des souches résistant aux antibiotiques courants.

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