Antibacterial substance be-24566b

Details Antibacterial substance be-24566b Antibacterial substance be-24566b

C - Chemistry, Metallurgy

12

P

C12P 17/18 (2006.01) A01N 43/90 (2006.01) A61K 31/35 (2006.01) C07D 493/08 (2006.01) C07H 19/01 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2082183

Abstract of the Disclosure Herein disclosed are an antibacterial substance: BE-24566B represented by the following structural formula (I): Image [I] or a pharmaceutically acceptable salt thereof; and an antibacterial agent comprising, as an essential component, the foreging antibacterial substance: BE-24566B or a pharmaceutically acceptable salt thereof. The antibacterial substance BE-24566B or pharmaceutically acceptable salts thereof can be prepared according to a process comprising the steps of inoculating an antibacterial substance: BE-24566B-producing micro- organism or a variant thereof into a culture medium to cultivate the microorganism or variant, in particular the strain FERM BP-3994 or a variant thereof, and isolating the intracellularly and/or extracellularly produced antibacterial substance. The substance BE- 24566B exhibits potent antibacterial effect on gram-positive bacteria represented by methicillin-resistant Staphylococcus aureus and, therefore, very useful as a therapeutic agent for treating a variety of infectious diseases caused by gram-positive bacteria.

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