C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/195 (2006.01) A23K 1/17 (2006.01) A61K 38/02 (2006.01) A61K 38/16 (2006.01) A61P 31/04 (2006.01) C07K 1/14 (2006.01) C07K 2/00 (2006.01) C12P 1/06 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2529124
The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors Al and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors Al and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and van comycin resistant strains, and is active also against some Gram-negative bacteria suchas M. catharralis, Neisseria species and H. influenzaeand Mycobacteria.
L'invention concerne une substance antibiotique d'origine microbienne, appelée arbitrairement antibiotique 107891, produit par fermentation de Microbispora sp. ATCC PTA-5024, ses sels pharmaceutiquement acceptables et ses compositions. L'invention concerne également son utilisation en tant qu'agent antibactérien présentant une activité inhibitrice versus des microbes susceptibles. L'antibiotique 107891, qui est un complexe comprenant deux facteurs, appelés A1 et A2, comprend une structure peptidique contenant de la lanthionine et de la méthyllanthionine comme constituants, ces dernières étant des caractéristiques typiques des antibiotiques des groupes lantibiotiques. L'antibiotique 107891 et ses facteurs A1 et A2 présentent une bonne activité antibactérienne contre des bactéries Gram positif comprenant des chaînes résistant à la méthicilline et à la vancomycine, et il est également actif contre des bactéries Gram négatif, telles que M. catharralis,des espèces de Neisseria et H.influenzae et des mycobactéries.
Candiani Gianpaolo
Ciciliato Ismaela
Gastaldo Luciano
Lazzarini Ameriga
Losi Daniele
Sentinella Pharmaceuticals Inc.
Sim & Mcburney
Vicuron Pharmaceuticals Inc.
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