Antibiotic ar-5 complex, derivatives thereof and methods for...

Details Antibiotic ar-5 complex, derivatives thereof and methods for... Antibiotic ar-5 complex, derivatives thereof and methods for...

C - Chemistry, Metallurgy

07

H

195/87, 260/230.

C07H 17/08 (2006.01) C07H 15/236 (2006.01) C12P 19/48 (2006.01) C12P 19/62 (2006.01)

Patent

CA 1158579

Disclosed are novel macrolide antibiotics of the formula I Image I wherein R is H or OH and A represents a double bond between the carbon atoms of positions 12 and 13 or, together with the carbon atoms of positions 12 and 13 an oxirane ring, as well as the pharmaceutically acceptable esters and salts thereof, The compounds can be prepared by fermentation of the novel species designated Micromonospora polytrota (e.g. M. poly- trota NRRL 12066). The compounds show antibacterial activity.

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