C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/95, 260/237.
C12P 17/18 (2006.01) C07D 498/18 (2006.01)
Patent
CA 1146887
Abstract of the Disclosure Antibiotic C-15003 PHO of the formula: Image wherein R1 is H, hydroxyl, alkanoyloxy, alkenylcarbonyloxy or arylcarbonyloxy; R2 is H, hydroxyl or alkanoyloxy; and R3 is H or alkanoyloxy, with the proviso that R1 and R2 are not both hydrogen; is produced by introducing a hydroxyl group into 15-position of a maytansinoid compound, and, of desired, thus obtained compound is subjected to deacylation or acylation. Antibiotic C-15003 PHO is useful as antiprotazoal or antitumor agent.
360469
Asai Mitsuko
Izawa Motowo
Nakahama Kazuo
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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