C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 477/00 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07D 477/20 (2006.01)
Patent
CA 2052942
ABSTRACT A dithioacetal carbapenem of the formula Image (I) in which R1 is hydrogen or C1-6 alkyl; n is 0, 1 or 2; R3 is hydrogen or C1-6 alkyl; R2 is C1-6 alkyl, phenyl optionally substituted with cyano, -CONH2, -CH2OH, -CH2NH2, CONHNH2 or with up to 5 halogen atoms, C1-6 alkyl or C1-6 alkyloxy groups, phenylmethyl optionally substituted with up to 5 halogen atoms, C1-6 alkyl or C1-6 alkyloxy groups on the phenyl ring, or a radical represented by the formula -(CH2)p-X in which p is 0 or 1; X is five-membered aromatic heterocyclic ring containing up to 1 sulfur, 1 oxygen or 4 nitrogen atoms, optionally substituted with a C1 -6 alkyl group, or six-membered aromatic heterocylic ring containing up to 4 nitrogen atoms, optionally substituted with a C1-6 alkyl group. or a non-toxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.
Bachand Carol
Daris Jean-Paul
Martel Alain
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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