A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 24/02 (2006.01) A61L 27/28 (2006.01) A61L 27/32 (2006.01) A61L 27/40 (2006.01) A61L 27/54 (2006.01) B05D 1/38 (2006.01)
Patent
CA 2432284
A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
L'invention se rapporte à un procédé d'application d'un revêtement contenant un agent thérapeutique tel qu'un antibiotique sur un implant effectué sur une zone à surface importante d'un implant métallique revêtu d'un phosphate de calcium servant de dépôt à l'agent thérapeutique. Cet implant est revêtu d'une ou plusieurs couches de minéraux de phosphate de calcium tels que hydroxyapatite. Après l'application de la couche cristalline, laquelle se fait habituellement au moyen d'une solution aqueuse, l'implant est séché et empaqueté. Juste avant l'implantation, l'implant est enlevé du paquet et la couche cristalline de phosphate de calcium est humidifiée avec la solution aqueuse contenant l'agent thérapeutique.
Higham Paul
Scott Christopher
Zitelli Joseph
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Howmedica Osteonics Corp.
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