Antibiotic carbapenem derivatives

Details Antibiotic carbapenem derivatives Antibiotic carbapenem derivatives

C - Chemistry, Metallurgy

07

D

C07D 477/00 (2006.01) A61K 31/40 (2006.01) C07D 207/12 (2006.01) C07D 207/16 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 477/20 (2006.01) C07F 7/10 (2006.01) C07F 9/547 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2107782

2107782 9217480 PCTABS00016 The present invention provides a compound of formula (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; n is zero or an integer 1 to 4; and P is a benzene ring substituted by groups R3 and R4 which are ortho with respect to one another wherein R3 and R4 are independently hydroxy or in vivo hydrolysable esters thereof; or P is a group of formula (II) or (III), wherein M is oxygen or a group NR5 wherein R5 is hydrogen or C1-4 alkyl; ring P being optionally further substituted; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof.

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