C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/62 (2006.01) A61K 38/12 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2747995
Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin Bi and [lie7] polymyxin Bi. The novel compounds have antibacterial properties against a diverse range of gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin B. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.
La présente invention concerne de nouveaux composés et de nouveaux composés protégés qui peuvent être dérivés de la polymyxine, y compris, par exemple, la polymyxine Bi et la polymyxine Bi [lie7]. Lesdits nouveaux composés possèdent des propriétés antibactériennes contre une gamme variée de bactéries à Gram négatif et une toxicité réduite comparée aux polymyxines telles que la polymyxine B. La présente invention porte en outre sur des compositions pharmaceutiques antibactériennes contenant lesdits nouveaux composés et de nouveaux composés protégés, ainsi que sur des procédés de préparation des composés antibactériens et des composés protégés.
Biosource Pharm Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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