Antibiotic compound

Details Antibiotic compound Antibiotic compound

C - Chemistry, Metallurgy

12

N

195/107, 530/7.0

C12N 1/20 (2006.01) C07K 5/117 (2006.01) C07K 7/06 (2006.01) C12P 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1198695

ABSTRACT A novel water-soluble peptide designated herein as Bu-2517 is produced by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962). The antibiotic exists in a cyclic depsipeptide structure and contains the amino acids D-serine, D-proline, L-proline, D-threo-.beta.-hydroxyaspartic acid, L- threo- .beta.-hydroxyaspartic acid, L-arginine and trans-L-3-hydroxy- proline and the residue of the C14 fatty acid, 3-hydroxytetra- decanoic acid. The Bu-2517 antibiotic inhibits the growth of a variety of aerobic and anaerobic gram-positive bacteria.

418544

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