Antibiotic compounds

Details Antibiotic compounds Antibiotic compounds

C - Chemistry, Metallurgy

07

D

C07D 477/00 (2006.01) A61K 31/40 (2006.01) C07D 207/16 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 477/20 (2006.01) C07F 7/10 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2106370

The present invention relates to carbapenems and provides a compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1- fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; R4 and R5 are the same or different and are selected from hydrogen, halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, C1-4alkoxycarbonyl, aminosulphonyl, C1-4alkylaminosulphonyl, di-C1-4alky- laminosulphonyl, carbamoyl, C1-4alkylcarbamoyl, di-C1-4alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C1-4alky- laxnino, di-C1-4alkylamino, C1-4alkanoylamino, C1-4alkanoyl(N C1-4alkyl)amino, C1-4alkanesulphonamido and C1-4al- kylS(O)n; wherein n is zero, one or two; with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to -NR3-. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

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