Antibiotic compounds

Details Antibiotic compounds Antibiotic compounds

C - Chemistry, Metallurgy

07

D

C07D 477/00 (2006.01) A61K 31/40 (2006.01) C07D 207/16 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 477/20 (2006.01) C07F 7/10 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2106141

A B S T R A C T ANTIBIOTIC COMPOUNDS The present invention provided a compound of the formula: Image (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: A is a group of the formula (IA) or (IB): Image (IA) Image (IB) R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 and R4 are the same or different and are a variety of substituents X is alkanediyl containing 1-6 carbon atoms optionally interrupted by O, S(O)x (wherein x is zero, one or two), -CONR5- or -NR5- wherein R5 is hydrogen or C1-4alkyl; or X is alkenediyl containing 2-6 carbon atoms optionally interrupted by O, S(O)x or -NR5- wherein x and R5 are as hereinbefore defined, with the provisos that: i) the interrupting function (O,S(O)x,NR5,-CONR5-) may be directly linked to the ring A, but is not directly linked to the -COOH function or to any carbon-carbon double bond in X; and (ii) when the interrupting function is -SO- or -SO2- it is not .beta. to the COOH function or .delta. if there is an intervening carbon-carbon double bond in X.

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