Antibiotic compounds

Details Antibiotic compounds Antibiotic compounds

C - Chemistry, Metallurgy

07

D

C07D 477/00 (2006.01) A61K 31/40 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 477/20 (2006.01) C07F 7/10 (2006.01) C07F 9/547 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2108356

The present invention relates to carbapenems and provides a compound of formula (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; and the thienyl ring is optionally further substituted by one or two substituents selected from halo, cyano, C1- 4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, trifluoromethyl, C1-4alkoxycarbonyl, amino; C1-4alkylamino, di-C1-4alkylamino, sulfonic acid, C1-4alkyS(O)n- (wherein n is 0-2), C1-4alkanoylamino, C1-4alkanoyl(N-C1-4alkyl)amino, carbamoyl, C1- 4alkylcarbamoyl, di-C1-4alkylcarbamoyl and N-C1-4alkanesulfonamido; or by a tetramethylene group attached to adjacent carbon atoms on the thienyl ring; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described.

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