Antibiotic compounds

Details Antibiotic compounds Antibiotic compounds

C - Chemistry, Metallurgy

07

D

C07D 499/88 (2006.01) A61K 31/43 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07F 7/10 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2106330

A B S T R A C T ANTIBIOTIC COMPOUNDS The present invention provides a compound of the formula (I) Image (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; Z is carboxy, sufonic acid, tetrazol-5-yl or C1-4alkylsulfonylcarbamoyl (-CONHSO2C1-4alkyl); A is a phenyl or thienyl ring; and A is optionally further substituted by one or two substituents or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

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