Antibiotic compounds and method of production thereof

Details Antibiotic compounds and method of production thereof Antibiotic compounds and method of production thereof

C - Chemistry, Metallurgy

07

H

260/230.54

C07H 15/22 (2006.01) C07H 15/234 (2006.01)

Patent

CA 1056824

ABSTRACT OF THE DISCLOSURE Compounds selected from the group consisting of 3"-N-demethylgentamicin C2 and 3"-N-demethylgentamicin C1, and being represented by the formula: Image wherein R1 is a hydrogen atom or methyl group, are prepared by reacting a compound represented by the formula: Image wherein R1 and R2 are hydrogen atoms or methyl groups with the proviso that when R1 is hydrogen atom, R2 is methyl group, with an oxidizing agent. The novel compounds display potent broad spectrum antibacterial activity, with less toxicity than gentamicin C1 and gentamicin C2.

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