C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 38/16 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2136103
The present invention provides substantially purified cryptdin peptides characterized as being cationic and between 30 and 40 amino acids in length, being found naturally in the epithelial cells of the small intestine, exhibiting specific antimicrobial activity against intestinal pathogens, and having a consensus amino acid sequence as follows: X1-C-X2-C-R-X3-C-X4-E-X5-G- X6-C-X7-C-C-X8, wherein X1 is 3-6 amino acids; X2 is one amino acid; X3 is 2 or 3 amino acids; X4 is three amino acids; X5 is three amino acids; X6 is one amino acid; X7 is 6 to 10 amino acids; and X8 is 0 to 7 amino acids. The preferred embodiments are illustrated as mouse cryptdin-1 (SEQ ID NO:9), mouse cryptdin-2 (SEQ ID NO:10), mouse cryptdin-3 (SEQ ID NO:11), mouse cryptdin-4 (SEQ ID NO:12), mouse cryptdin-5 (SEQ ID NO:13), and rat cryptdin-1 (SEQ ID NO:14). The present invention provides a method for detecting inflammatory pathologies in a subject and, further, provides a method for treating an infectious process by the administration of the cryptdin peptides in a physiologically acceptable medium.
Miller Samuel I.
Ouellette Andre J.
Selsted Michael E.
Shriner's Hospital For Crippled Children
Smart & Biggar
Sydel (s.a.)
The General Hospital Corporation
The Regents Of The University Of California
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