Antibiotic efrotomycin from streptomyces lactamdurans

C - Chemistry – Metallurgy – 12 – P

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195/103, 195/72,

C12P 19/00 (2006.01) C07H 3/06 (2006.01)

Patent

CA 1039215

ABSTRACT OF THE DISCLOSURE This invention relates to a new antibiotic agent which also possesses growth promoting activity, isolated from the fermentation broth of Streptomyces lactamdurans by solvent extraction, and designated FR-02A. FR-02A is an antibiotic which is effective against both gram-positive and gram-negative bacteria, and accordingly may be used in the treatment of a broad spectrum of infections in animals. More particularly, FR-02A is effective against PPLO in chickens, pigs and cattle. It is effective against mouse coccidiosis and the most prevalent types of chicken coccidiosis. It is efficacious subcu- taneously against M. galliscpticum air sacculitis in broil- ers, and orally effective in mice in systemic infections produced by Bordetella bronchiseptica. Furthermore, FR-02A can be used as a growth promoting agent for animals such as chickens, pigs and cattle.

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