C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/101, 530/15.
C12P 1/04 (2006.01) A23K 1/17 (2006.01) A61K 35/74 (2006.01) C07G 11/00 (2006.01) C12N 1/20 (2006.01) C12P 1/06 (2006.01)
Patent
CA 1302926
ABSTRACT An antibiotic F-0769 having the following properties: (1) Outer appearance: White or light yellow powder, (2) Melting point: 245-250°C, (3) Specific rotation: Image = -37.5° (c=1, methanol), (4) Solubility in solvents: Soluble in methanol, ethanol, acetone, chloroform, ethyl acetate and benzene; and insoluble in water and hexane, (5) Elementary analysis (found %): C:57.53, H:7.36, O:21.17, N:12.97, (6) Ultraviolet absorption spectrum (as measured in methanol: As shown in Figure 1, Image = 213 nm (466), 286 nm (200) (7) Infrared absorption spectrum (as measured by KBr method): As shown in Figure 2, (8) Nuclear magnetic resonance spectra as measured in heavy chloroform): 1H-NMR spectrum is as shown in Figure 3, and 13C-NMR spectrum is as shown in Figure 4, (9) Distinction among basicity, acidity and neutrality: Neutral substance, (10) Amino acid analysis: As a result of the hydrolysis with 6N hydrochloric acid at 110°C for 18 hours, amino acids i.e. threonine, valine and leucine were detected, (11) Color reactions: Positive in the iodine reaction and in the potassium permanganate reaction; and negative in the ninhydrin reaction and in the ferric chloride reaction, (12) Thin layer chromatography (by means of silica gel, Art. 5715, manufactured by Merck Co.): Image (13) Molecular weight (as measured by Rast method): About 745
530615
Miyazaki Yukio
Seino Akio
Sugawara Hideo
Sugiyama Machiko
Takahashi Nobuko
Kaken Pharmaceutical Co. Ltd.
Marks & Clerk
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