Antibiotic formulation and a method of making this formulation

A - Human Necessities – 61 – K

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Details

A61K 31/545 (2006.01) A61K 9/08 (2006.01) A61K 31/43 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2468679

An antibiotic formulation in a true solution is provided. This formulation includes an antibiotic and N-methyl-2-pyrrolidone. It also may include a preservative, an antioxidant, and/or an additive. The antibiotic is a beta lactam, such as a penicillin, a cephalosporin, other beta lactams, or combinations thereof. The formulation is made by dissolving the antibiotic in the N-methyl-2-pyrrolidone. The antibiotic formulation is suitable for use at temperatures below about 0 ~C and without agitation. Further, the antibiotic formulation in true solution can be made with non-sterile ingredients and can be filtered to remove impurities.

L'invention porte sur une préparation antibiotique dans une solution authentique comprenant un antibiotique, de la N-méthyl-2-pyrrolidone et facultativement un conservateur, un antioxydant et/ou un additif. L'antibiotique est un .beta. lactame tel que de la pénicilline, de la céphalosporine, d'autres .beta. lactame ou leur combinaisons. Ladite préparation, qui s'obtient par dissolution de l'antibiotique dans la N-méthyl-2-pyrrolidone, peut s'utiliser à moins d'environ 0 ·C et sans agitation, peut comporter des ingrédients non stériles, et peut être filtrée pour en éliminer les impuretés.

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