Antibiotic neplanocins

C - Chemistry – Metallurgy – 07 – G

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C07G 11/00 (2006.01) C07D 473/00 (2006.01) C07H 19/16 (2006.01) C12P 19/28 (2006.01) C12P 19/40 (2006.01)

Patent

CA 1128882

ABSTRACT OF THE DISCLOSURE The present invention provides antibiotic neplanocins of the following formula Image wherein X is an NH2, -OH, -SH, or -SCH3 group or a C1 atom, R is a hydrogen atom or a protective group for the -OH group, and Z is the group; Image in which Y is -O- or a valence bond, and R is a hydrogen atom or a protective group for the -OH group, or the group; Image in which Y is -O- or a valence bond. They are prepared by a process which comprises culturing a neplanocins producing microorganism belonging to the genus Ampullariella in a nutrient medium consisting of assimilable carbon and nitrogen sources and inorganic substances, and isolating neplanocin-A, -C, -D, -B and -F from the cultured mass.

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