A - Human Necessities – 23 – K
Patent
A - Human Necessities
23
K
99/28, 167/103.6
A23K 1/17 (2006.01) A61K 37/02 (1980.01) A61K 31/71 (1980.01)
Patent
CA 1175748
Abstract The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) Image In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or func- tionally modified hydroxy or amino. (II) Image In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.
369055
Baschang Gerhard
Hartmann Albert
Stanek Jaroslav
Tarcsay Lajos
Fetherstonhaugh & Co.
Novartis Ag
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